Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
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چکیده
منابع مشابه
Optogenetic dissection of entorhinal-hippocampal functional connectivity.
We used a combined optogenetic-electrophysiological strategy to determine the functional identity of entorhinal cells with output to the place-cell population in the hippocampus. Channelrhodopsin-2 (ChR2) was expressed selectively in the hippocampus-targeting subset of entorhinal projection neurons by infusing retrogradely transportable ChR2-coding recombinant adeno-associated virus in the hipp...
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Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive aging. Using the tau PET agent (18)F-AV-1451, we examined retention patterns in cognitively normal older people in relation to young controls and AD patients. Age and β-amyloid (measured using PiB PET) were differentially associated with tau tracer retention in healthy aging. Older age was related to inc...
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Functional connectivity of the entorhinal–hippocampal space circuit
The mammalian space circuit is known to contain several functionally specialized cell types, such as place cells in the hippocampus and grid cells, head-direction cells and border cells in the medial entorhinal cortex (MEC). The interaction between the entorhinal and hippocampal spatial representations is poorly understood, however. We have developed an optogenetic strategy to identify function...
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A major task of contemporary cognitive neuroscience of aging is to explain why episodic memory declines. Change in resting-state Functional Connectivity (rsFC) could be a mechanism accounting for reduced function. We addressed this through three studies. In Study 1, 119 healthy participants (2083 years) were followed for 3.5 years with verbal recall testing and MRI. Independently of atrophy, re...
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ژورنال
عنوان ژورنال: eLife
سال: 2019
ISSN: 2050-084X
DOI: 10.7554/elife.49132